Journal: Cancers

Article Title: NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models

doi: 10.3390/cancers12020381

Figure Lengend Snippet: The number of statistically significant gene sets from gene set enrichment analysis (GSEA) with a false discovery rate (FDR) < 0.05 for each dataset for the major molecular signatures database collections (i.e., C5, C2, and C6). The black bars represent the unaltered genes and the white bars represent the annotated gene sets.

Article Snippet: Using Cytoscape’s enrichment mapper, 63 statistically significant GSEA gene sets from the Gene Ontology (C5) database had a FDR < 25% in 50% or more of the GeneLab datasets analyzed.

Techniques:

Journal: Cancers

Article Title: NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models

doi: 10.3390/cancers12020381

Figure Lengend Snippet: Principal component analysis (PCA) plots on GLDS datasets using the gene set enrichment analysis (GSEA) nominal enrichment scores before (top row) and after (bottom row) auto-annotation using Cytoscape’s enrichment map software. GSEA gene sets used were as follows: ( A , B ) C5 Gene Ontology (GO) terms, ( C , D ) C2 curated terms, and ( E , F ) C6 oncogenic signature terms. Each data point is represented by experimental radiation dose (color) or radiation type (shape).

Article Snippet: Using Cytoscape’s enrichment mapper, 63 statistically significant GSEA gene sets from the Gene Ontology (C5) database had a FDR < 25% in 50% or more of the GeneLab datasets analyzed.

Techniques: Software